What is a neurodegenerative disease?


Neurodegenerative diseases occur when nerve cells in the brain or peripheral nervous system lose function over time and ultimately die. Although treatments may help relieve some of the physical or mental symptoms associated with neurodegenerative diseases, there is currently no way to slow disease progression and no known cures.

Key research challenges are identifying and measuring exposures that may have occurred before an individual is diagnosed and disentangling the effects of these exposures.

A Global Issue

A local response

As of 2019, there were 703M persons aged 65 years or over in the world.

This population will double by 2050, and as a result neurological diseases will become more prevalent.

Projected number of people age 65 and older in the U.S. population with Alzheimer's dementia, 2010 to 2050
  • 1 in 5 women and 1 in 10 men will develop Alzheimer’s disease in their lifetime; people of color are 2x as likely (Tulane)
  • Currently, 5 million Americans suffer from Alzheimer's disease; 1M from Parkinson's; 400K from multiple sclerosis; 30K from amyotrophic lateral sclerosis (Harvard)
  • If left unchecked, more than 12 million Americans will suffer from neurodegenerative diseases in 30 years (Harvard)